Bioavailability of the Fusarium toxin deoxynivalenol (DON) from wheat straw and chaff in pigs

Publication Type

Journal contribution (peer reviewed)

Authors

Rohweder D, Kersten S, Valenta H, Sondermann S, Schollenberger M, Drochner W and Dänicke S.

Year of publication

2013

Published in

Archives of Animal Nutrition

Band/Volume

67/1

DOI

10.1080/1745039X.2012.755328

Page (from - to)

37-47

Keywords

Deoxynivalenol, Schwein, Spreu, Stroh, Weizen

<p><span style="font-family: 'Arial','sans-serif'; font-size: 12pt; mso-fareast-font-family: Calibri; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA; mso-fareast-theme-font: minor-latin;">Fusarium infections do not only affect the grain, but also the rest of<br />the plant, which result in contamination of plants with the mycotoxin<br />deoxynivalenol (DON). The bioavailability of DON may be influenced by the<br />matrix due to the differences in nutrient composition between grain and straw,<br />particularly the high fibre component in straw. The experiment was carried out<br />by exposing 18 male castrated pigs (30&ndash;40 kg live weight) with a single dose of<br />DON from wheat grain, straw and chaff in the diet. The courses of DON serum<br />concentrations were evaluated using toxicokinetic methods. The absorption of<br />DON was not influenced by the source of DON. The invasion half-life of DON from<br />grain, straw and chaff amounted to 0.76, 0.77 and 0.48 h, respectively, and<br />were not significantly different. The elimination of DON was also not affected<br />by the DON source. The bioavailability of DON, calculated by the dose corrected<br />area under the curve of the serum-DON-concentrations, amounted to 81.9, 87.3<br />and 109.8% for straw, grain and chaff, respectively, without significant<br />differences. Thus, the uptake of DON from straw may contribute comparably to<br />the overall exposure of animals.</span></p>