Parameters of metabolism affected by limited loads of isolated DON (Deoxynivalenol) in growing pigs.
- Publikations-Art
- Kongressbeitrag
- Autoren
- Drochner, W., Schollenberger, M., Götz, S., Lauber, U., Morar, M.V. and Rüfle, M.
- Erscheinungsjahr
- 2004
- Veröffentlicht in
- Bulletin of the University of Agricultural Sciences and Veterinary Medicine
- Herausgeber
- University of Agricultural Sciences and Veterinary Medicine
- Verlag
- Academic Press (Ed.) , Cluj-Napoca (Rumänien)
- Serie/Bezeichnung
- Buletinul
- Seite (von - bis)
- 1-5
- Tagungsname
- Prospects of the 3rd Millenium Agriculture.
- Tagungsort
- Cluj-Napoca
- Tagungsdatum
- 20.-23.10.2004
- Schlagworte
- Deoxynivalenol, hemoglobin, IgA, metabolism, pig
Deoxynivalenol is a toxin, produced by different fusarium strains. It is found world wide in cereals with quite high frequency but mostly in limited concentrations. So tolerance levels between 500 ug for human beings and 1,0 mg/ kg for piglets are discussed. A long time intake of related concentrations by human beings might include risks. So it is of importance to study subclinical effects of these toxins with limited dosages in piglets (300, 600, 1200 microgram per kg feed, 9 pigs per group, 8 weeks, control with no toxin load). The pig proved to be a good model to study these effects in relation to metabolism of humans. The following results should be pointed out: Limited dosages for 8 weeks in piglets result in subclinical effects. IgA-level increase, hemoglobin and GOT-level in the blood increase, glucose is reduced, IgF1 and cortisol were not significantly affected. Limited glucose absorption and impaired protein metabolism result in increasing urea levels in the blood. Corresponding regressions were highly significant. The results show, that protein metabolism at the level of toxins added, is already affected. Liver enzymes, as for instance ASAT, show, that a certain increase of concentrations is statistically significant. The importance of these findings for life long intake of these toxins by human beings through cereals is discussed.